Volume I contains a comprehensive set of background chapters on neurogastroenterology (basic science and physiology); pharmacology, pharmacokinetics and pharmacogenomics; age, gender, women’s health and the patient’s perspective; cross-cultural aspects of FGIDs; the role of the microenvironment (food and microbiota); and biopsychosocial aspects of assessment and management.

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Volume II provides the key clinical information on 33 adult and 17 pediatric FGIDs from esophagus to anorectum, as well as a newly developed chapter on centrally mediated disorders of gastrointestinal pain. For each FGID we provide recent information on the epidemiology, pathophysiology, and psychosocial aspects along with evidence- and consensus-based recommendations on diagnosis and treatment. Volume II also contains new information and the revised Rome IV diagnostic criteria for adult and pediatric FGIDs. Also there are appendices that contain key reference information including the Rome IV diagnostic criteria tables, a comparison of the Rome III and Rome IV criteria, a flowchart to assist in the biopsychosocial assessment of patients with FGIDs and how to treat or when to seek a mental health consultant. There are also the validated Rome IV pediatric and adult questionnaires criteria for epidemiological and clinical research.

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The diagnostic criteria, designed primarily for research, has a limited role in clinical practice. Patients don’t go to doctors complaining of IBS, or sphincter of Oddi dysfunction; they present with symptoms of abdominal pain, nausea, vomiting and constipation, among others. Accordingly, the Foundation initiated a multiyear committee process to address this concern by incorporating diagnostic decision making, information about testing and the use of the symptom-based criteria into a series of clinical algorithms.

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The MDCP redefines the ways in which clinicians can care for patients having even the most complex functional GI disorders. The 2nd edition is a case-based learning module that updates the content of the first MDCP book published in 2015. There are over 70 cases, more than double that in the first edition, and all cases are revised to meet the Rome IV diagnostic standards.

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