|
- Alexander F. Psychosomatic medicine: Its principles and applications. New York: W.W. Norton, 1950.
- Engel GL, Reichsman F, Segal HL. A study of an infant with a gastric fistula. I. Behavior and the rate of total hydrochloric acid secretion. Psychosom Med 1956;18:374-398.
- Engel GL. The need for a new medical model: a challenge for biomedicine. Science 1977;196:129-136.
- Drossman DA, Li Z, Leserman J, et al. Health status by gastrointestinal diagnosis and abuse history. Gastroenterology 1996;110:999-1007.
- Sandler RS, Drossman DA, Nathan HP, et al. Symptom complaints and health care seeking behavior in subjects with bowel dysfunction. Gastroenterology 1984;87:314-318.
- Locke GI, Zinsmeister A, Talley N, et al. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 2000;75:907-912.
- Bode G, Brenner H, Adler G, et al. Recurrent abdominal pain in children: evidence from a population-based study that social and familial factors play a major role but not Helicobacter pylori infection. J Psychosom Res 2003;54:417-421.
- Levy RL, Whitehead WE, Von Korff MR, et al. Intergenerational transmission of gastrointestinal illness behavior. Am J Gastroenterol 2000;95:451-456.
- Walker LS, Garber J, Greene JW. Somatization symptoms in pediatric abdominal pain patients: Relation to chronicity of abdominal pain and parent somatization. J Abnorm Child Psychol 1991;19:379-394.
- Walker LS, Garber J, Greene JW. Somatic complaints in pediatric patients: A prospective study of the role of negative life events, child social and academic competence, and parental somatic symptoms. J Consult Clin Psychol 1994;62:1213-1221.
- Levy RL, Jones KR, Whitehead WE, et al. Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology. Gastroenterology 2001;121:799-804.
- Levy RL, Whitehead WE, Walker LS, et al. Increased somatic complaints and health-care utilization in children: Effects of parent IBS status and parent response to gastrointestinal symptoms. Am J Gastroenterol 2004;99:2442-2451.
- Walker LS, Williams SE, Smith CA, et al. Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain. Pain 2006;122:43-52.
- Caes L, Vervoort T, Devos P, et al. Parental distress and catastrophic thoughts about child pain: Implications for parental protective behavior in the context of child leukemia related medical procedures. Clin J Pain 2013;ahead of print.
- Levy RL, Langer S, Walker L, et al. Twelve month follow-up of cognitive behavioral therapy for children with functional abdominal pain. JAMA Pediatr 2013;167:178-184.
- Levy RL, Langer SL, Walker LS, et al. Cognitive-behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms. Am J Gastroenterol 2010;105:946-956.
- Levy RL, Langer SL, Romano JM, et al. Cognitive mediators of treatment outcomes in pediatric functional abdominal pain. Clin J Pain 2014:Epub ahead of print.
- Seino S, Watanabe S, Ito N, et al. Enhanced auditory brainstem response and parental bonding style in children with gastrointestinal symptoms. PLoS One 2012;7:e32913.
- Campo JV, Bridge J, Lucas A, et al. Physical and emotional health of mothers of youth with functional abdominal pain. Arch Pediatr Adolesc Med 2007;161:131-137.
- Goubert L, Vervoort T, De Ruddere L, et al. The impact of parental gender, catastrophizing and situational threat upon parental behaviour to child pain: a vignette study. Eur J Pain 2012;16:1176-1184.
- Levy RL, Langer SL, Walker LS, et al. Relationship between the decision to take a child to the clinic for abdominal pain and maternal psychological distress. Arch Pediatr Adolesc Med 2006;160:961-965.
- Langer SL, Romano JM, Levy RL, et al. Catastrophizing and parental response to child symptom complaints. Child Health Care 2009;38:169-184.
- Langer SL, Walker LS, Romano JM, et al. Predictors of maternal responses to child abdominal pain. Child Health Care 2007;36:63-81.
- Bradford K, Shih W, Videlock EJ, et al. Association between early adverse life events and irritable bowel syndrome. Clin Gastroenterol Hepatol 2012;10:385-390.
- Leserman J, Drossman DA. Relationship of abuse history to functional gastrointestinal disorders and symptoms: Some possible mediating mechanisms. Trauma Violence Abuse 2007;8:331-343.
- Drossman DA. Abuse, trauma, and GI illness: Is there a link? Am J Gastroenterol 2011;106:14-25.
- Creed F, Levy R, Bradley L, et al. Psychosocial aspects of functional gastrointestinal disorders. McLean, VA: Degnon Associates, Inc, 2006.
- Longstreth GF, Wolde-Tsadik G. Irritable bowel-type symptoms in HMO examinees: Prevalence, demographics, and clinical correlates. Dig Dis Sci 1993;38:1581-1589.
- Galli N. The influence of cultural heritage on the health status of Puerto Ricans. J Sch Health 1975;45:10-16.
- Quigley EM, Sperber AD, Drossman DA. WGO—Rome foundation joint symposium summary: IBS—the global perspective. J Clin Gastroenterol 2011;45:i-ii.
- Alander T, Heimer G, Svardsudd K, et al. Abuse in women and men with and without Functional Gastrointestinal Disorders. Dig Dis Sci 2008;53:1856-1864.
- Drossman DA, Creed FH, Olden KW, et al. Psychosocial aspects of the functional gastrointestinal disorders. Gut 1999;45:II25-II30.
- Koloski NA, Talley NJ, Boyce PM. A history of abuse in community subjects with irritable bowel syndrome and functional dyspepsia: the role of other psychosocial variables. Digestion 2005;72:86-96.
- Drossman DA, Ringel Y. Psychosocial factors in ulcerative colitis and crohn’s disease. In: Sartor BR, Sandborn WJ, eds. Kirsner’s inflammatory bowel disease. 6th ed. London: Saunders, 2004:340-356.
- Thomas JD. Gypsies and American medical care. Ann Intern Med 1985;102:842-845.
- American Psychiatric Association. Multiaxial assessment. Diagnostic and statistical manual of mental disorders DSM-IV-TR. 4th ed, 2000:1-8.
- Drossman DA, Chang L. Psychosocial factors in the care of patients with GI disorders. In: Yamada T, ed. Textbook of gastroenterology. Philadelphia: Lippincott-Raven, 2003:636-654.
- Murray CD, Flynn J, Ratcliffe L, et al. Effect of acute physical and psychological stress on gut autonomic innervation in iritable bowel syndrome. Gastroenterology 2004;127:1695-1703.
- Sperber AD, Drossman DA. Review article: The functional abdominal pain syndrome. Aliment Pharmacol Ther 2011;33:514-524.
- Hsu LK, Folstein MF. Somatoform disorders in Caucasian and Chinese Americans. J Nerv Ment Dis 1997;185:382-287.
- Mead M. Sex and temperament in three primitive societies. New York: New American Library, 1950.
- Spiller R, Lam C. An update on post-infectious irritable bowel syndrome: Role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil 2012;18:258-268.
- Drossman DA, McKee DC, Sandler RS, et al. Psychosocial factors in the irritable bowel syndrome: A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology 1988;95:701-708.
- Blanchard EB, Lackner JM, Jaccard J, et al. The role of stress in symptom exacerbation among IBS patients. J Psychosom Res 2008;64:119-128.
- Bitton A, Dobkin PL, Edwardes MD, et al. Predicting relapse in Crohn’s disease: A biopsychosocial model. Gut 2008;57:1386-1392.
- Drossman DA, Li Z, Leserman J, et al. Effects of coping on health outcome among female patients with gastrointestinal disorders. Psychosom Med 2000;62:309-317.
- van Tilburg MA, Palsson OS, Whitehead WE. Which psychological factors exacerbate irritable bowel syndrome? Development of a comprehensive model. J Psychosom Res 2013;74:486-492.
- Przekop P, Haviland MG, Zhao Y, et al. Self-reported physical health, mental health, and comorbid diseases among women with irritable bowel syndrome, fibromyalgia, or both compared with healthy control respondents. J Am Osteopath Assoc 2012;112:726-735.
- Lackner JM, Gurtman MB. Pain catastrophizing and interpersonal problems: a circumplex analysis of the communal coping model. Pain 2004;110:597-604.
- Granot M, Ferber SG. The roles of pain catastrophizing and anxiety in the prediction of postoperative pain intensity. Clin J Pain 2006;21:439-445.
- Sperber AD, Drossman DA, Quigley E. The global perspective on irritable bowel syndrome: A Rome Foundation-World Gastroenterology Organization symposium. Am J Gastroenterol 2012;107:1602-1609.
- Lackner JM, Quigley BM. Pain catastrophizing mediates the relationship between worry and suffering in patients with irritable bowel syndrome. Behav Res Ther 2005;43:943-957.
- Bennett EJ, Tennant CC, Piesse C, et al. Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut 1998;43:256-261.
- Lackner JM, Gudleski GD, Firth R, et al. Negative aspects of close relationships are more strongly associated than supportive personal relationships with illness burden of irritable bowel syndrome. J Psychosom Res 2013;74:493-500.
- Jakobsson Ung E, Ringstrom G, Sjovall H, et al. How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study. Eur J Gastroenterol Hepatol 2013;25:1478-1483.
- Lackner JM, Brasel AM, Quigley BM, et al. The ties that bind: Perceived social support, stress, and IBS in severely affected patients. Neurogastroenterol Motil 2010;22:893-900.
- Conboy LA, Macklin E, Kelley J, et al. Which patients improve: characteristics increasing sensitivity to a supportive patient-practitioner relationship. Soc Sci Med 2010;70:479-484.
- Gerson MJ, Gerson CD. The importance of relationships in patients with irritable bowel syndrome: A review. Gastroenterol Res Pract 2012;2012:1-5.
- Singh P, Agnihotri A, Pathak MK, et al. Psychiatric, somatic and other functional gastrointestinal disorders in patients with irritable bowel syndrome at a tertiary care center. J Neurogastroenterol Motil 2012;18:324-331.
- Lee V, Guthrie E, Robinson A, et al. Functional bowel disorders in primary care: factors associated with health-related quality of life and doctor consultation. J Psychosom Res 2008;64:129-138.
- Hu WH, Wong WM, Lam CL, et al. Anxiety but not depression determines health care-seeking behaviour in Chinese patients with dyspepsia and irritable bowel syndrome: a population-based study. Aliment Pharmacol Ther 2002;16:2081-2088.
- Tosic-Golubovic S, Miljkovic S, Nagorni A, et al. Irritable bowel syndrome, anxiety, depression and personality characteristics. Psychiatr Danub 2010;22:418-424.
- Hillila MT, Hamalainen J, Heikkinen ME, et al. Gastrointestinal complaints among subjects with depressive symptoms in the general population. Aliment Pharmacol Ther 2008;28:648-654.
- Palsson OS, Drossman DA. Psychiatric and psychological dysfunction in irritable bowel syndrome and the role of psychological treatments. Gastroenterol Clin North Am 2005;34:281-303.
- Gwee KA. Post-infectious irritable bowel syndrome, an inflammation-immunological model with relevance for other IBS and functional dyspepsia. J Neurogastroenterol Motil 2010;16:30-34.
- Dai C, Jiang M. The incidence and risk factors of post-infectious irritable bowel syndrome: A meta-analysis. Hepatogastroenterology 2012;59:67-72.
- Cho HS, Park JM, Lim CH, et al. Anxiety, depression and quality of life in patients with irritable bowel syndrome. Gut Liver 2011;5:29-36.
- Bouchoucha M, Hejnar M, Devroede G, et al. Anxiety and depression as markers of multiplicity of sites of functional gastrointestinal disorders: A gender issue? Clin Res Hepatol Gastroenterol 2013;37:422-430.
- Piacentino D, Cantarini R, Alfonsi M, et al. Psychopathological features of irritable bowel syndrome patients with and without functional dyspepsia: A cross sectional study. BMC Gastroenterol 2011;11:94.
- Muscatello MR, Bruno A, Pandolfo G, et al. Depression, anxiety and anger in subtypes of irritable bowel syndrome patients. J Clin Psychol Med Settings 2010;17:64-70.
- Addolorato G, Mirijello A, D’Angelo C, et al. State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting. Int J Clin Pract 2008;62:1063-1069.
- Canavan JB, Bennett K, Feely J, et al. Significant psychological morbidity occurs in irritable bowel syndrome: a case-control study using a pharmacy reimbursement database. Aliment Pharmacol Ther 2009;29:440-449.
- Kabra N, Nadkarni A. Prevalence of depression and anxiety in irritable bowel syndrome: A clinic based study from India. Indian J Psychiatry 2013;55:77-80.
- Lee HJ, Lee SY, Kim JH, et al. Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome. Gen Hosp Psychiatry 2010;32:499-502.
- Van Oudenhove L, Vandenberghe J, Vos R, et al. Factors associated with co-morbid irritable bowel syndrome and chronic fatigue-like symptoms in functional dyspepsia. Neurogastroenterol Motil 2011;23:524-e202.
- Miller V, Hopkins L, Whorwell PJ. Suicidal ideation in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2004;2:1064-1068.
- Mak AD, Wu JC, Chan Y, et al. Dyspepsia is strongly associated with major depression and generalised anxiety disorder—a community study. Aliment Pharmacol Ther 2012;36:800-810.
- Van Oudenhove L, Vandenberghe J, Vos R, et al. Risk factors for impaired health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther 2010;33:261-274.
- Lackner JM, Gurtman MB. Patterns of interpersonal problems in irritable bowel syndrome patients: a circumplex analysis. J Psychosom Res 2005;58:523-532.
- Kovacs Z, Kovacs F. Depressive and anxiety symptoms, dysfunctional attitudes and social aspects in irritable bowel syndrome and inflammatory bowel disease. Int J Psychiatry Med 2007;37:245-255.
- Thijssen AY, Jonkers DM, Leue C, et al. Dysfunctional cognitions, anxiety and depression in irritable bowel syndrome. J Clin Gastroenterol 2010;44:e236-241.
- Modabbernia MJ, Mansour-Ghanaei F, Imani A, et al. Anxiety-depressive disorders among irritable bowel syndrome patients in Guilan, Iran. BMC Res Notes 2012;5:112.
- Mykletun A, Jacka F, Williams L, et al. Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women. BMC Gastroenterol 2010;10:88.
- Resendiz-Figueroa FE, Ortiz-Garrido OM, Pulido D, et al. Impact of the anxiety characteristics and depression on clinical aspects and quality of life in patients with irritable bowel syndrome. Rev Gastroenterol Mex 2008;73:3-10.
- Myers B, Greenwood-Van Meerveld B. Role of anxiety in the pathophysiology of irritable bowel syndrome: Importance of the amygdala. Front Neurosci 2009;10:47.
- Sugaya N, Yoshida E, Yasuda S, et al. Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients. Psychiatry Clin Neurosci 2013;67:397-404.
- Keough ME, Timpano KR, Zawilinski LL, et al. The association between irritable bowel syndrome and the anxiety vulnerability factors: body vigilance and discomfort intolerance. J Health Psychol 2011;16:91-98.
- van Oudenhove L, Vandenberghe J, Geeraerts B, et al. Relationship between anxiety and gastric sensorimotor function in functional dyspepsia. Psychosom Med 2007;69:455-463.
- Bengtsson M, Sjoberg K, Candamio M, et al. Anxiety in close relationships is higher and self-esteem lower in patients with irritable bowel syndrome compared to patients with inflammatory bowel disease. Eur J Intern Med 2013;24:266-272.
- Lee S, Wu J, Ma YL, et al. Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study. Aliment Pharmacol Ther 2009;30:643-651.
- Sykes MA, Blanchard EB, Lackner J, et al. Psychopathology in irritable bowel syndrome: support for a psychophysiological model. J Behav Med 2003;26:361-372.
- Keefer L, K. S, M.A. S, et al. Towards a better understanding of anxiety in irritable bowel syndrome: A preliminary look at worry and intolerance of uncertainty. J Cogn Psychother 2005;19:163-172.
- Cheng C, Chan AO, Hui WM, et al. Coping strategies, illness perception, anxiety and depression of patients with idiopathic constipation: a population-based study. Aliment Pharmacol Ther 2003;18:319-326.
- Lydiard RB. Increased prevalence of functional gastrointestinal disorders in panic disorder: clinical and theoretical implications. CNS Spectr 2005;10:899-908.
- Kaplan DS, Masand PS, Gupta S. The relationship of irritable bowel syndrome (IBS) and panic disorder. Ann Clin Psychiatry 1996;8:81-88.
- Dammen T, Ekeberg O, Arnesen H, et al. Health-related quality of life in non-cardiac chest pain patients with and without panic disorder. Int J Psychiatry Med 2008;38:271-286.
- Kang JM. Pathophysiological and psychosocial features in functional vomiting. J Neurogastroenterol Motil 2010;16:448.
- Lydiard RB, Greenwald S, Weissman MM, et al. Panic disorder and gastrointestinal symptoms: Findings from the NIMH Epidemiologic Catchment Area Project. Am J Psychiatry 1994;151:64-70.
- Sugaya N, Kaiya H, Kumano H, et al. Relationship between subtypes of irritable bowel syndrome and severity of symptoms associated with panic disorder. Scand J Gastroenterol 2008;43:675-681.
- Kim JE, Dager SR, Lyoo IK. The role of the amygdala in the pathophysiology of panic disorder: Evidence from neuroimaging studies. Biol Mood Anxiety Disord 2012;2:20.
- Abelson JL, Khan S, Liberzon I, et al. HPA axis activity in patients with panic disorder: Review and synthesis of four studies. Depress Anxiety 2007;24:66-76.
- Creed F, Ratcliffe J, Fernandes L, et al. Outcome in severe irritable bowel syndrome with and without accompanying depressive, panic and neurasthenic disorders. Br J Psychiatry 2005;186:507-515.
- Kendall-Tackett KA. Physiological correlates of childhood abuse: chronic hyperarousal in PTSD, depression, and irritable bowel syndrome. Child Abuse Negl 2000;24:799-810.
- Danese A, McEwen BS. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav 2012;106:29-39.
- Korte SM, Koolhaas JM, Wingfield JC, et al. The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neurosci Biobehav Rev 2005;29:3-38.
- Irwin C, Falsetti SA, Lydiard RB, et al. Comorbidity of postraumatic stress disorder and irritable bowel syndrome. J Clin Psychiatry 1996;57:576--581.
- White DL, Savas LS, Daci K, et al. Trauma history and risk of the irritable bowel syndrome in women veterans. Aliment Pharmacol Ther 2010;32:551-561.
- Savas LS, White DL, Wieman M, et al. Irritable bowel syndrome and dyspepsia among women veterans: Prevalence and association with psychological distress. Aliment Pharmacol Ther 2009;29:115-125.
- Graham DP, Savas L, White D, et al. Irritable bowel syndrome symptoms and health-related quality of life in female veterans. Aliment Pharmacol Ther 2010;31:261-273.
- Goodwin L, Bourke JH, Forbes H, et al. Irritable bowel syndrome in the UK military after deployment to Iraq: what are the risk factors? Soc Psychiatry Psychiatr Epidemiol 2013;48:1755-1765.
- Trivedi KH, Schlett CD, Tribble DR, et al. The impact of post-infectious functional gastrointestinal disorders and symptoms on the health-related quality of life of US military personnel returning from deployment to the Middle East. Dig Dis Sci 2011;56:3602-3609.
- Masand PS, Keuthen NJ, Gupta S, et al. Prevalence of irritable bowel syndrome in obsessive-compulsive disorder. CNS Spectr 2006;11:21-25.
- Gros DF, Antony MM, McCabe RE, et al. Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression. J Anxiety Disord 2009;23:290-296.
- Lydiard RB, Fossey MD, Marsh W, et al. Prevalence of psychiatric disorders in patients with irritable bowel syndrome. Psychosomatics 1993;34:229-234.
- Tang TN, Toner BB, Stuckless N, et al. Features of eating disorders in patients with irritable bowel syndrome. J Psychosom Res 1998;45:171-178.
- Abraham S, Kellow J. Exploring eating disorder quality of life and functional gastrointestinal disorders among eating disorder patients. J Psychosom Res 2011;70:372-377.
- Cremonini F, Camilleri M, Clark MM, et al. Associations among binge eating behavior patterns and gastrointestinal symptoms: a population-based study. Int J Obes (Lond) 2009;33:342-353.
- Javaras KN, Pope HG, Lalonde JK, et al. Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry 2008;69:266-273.
- Crowell MD, Cheskin LJ, Musial F. Prevalence of gastrointestinal symptoms in obese and normal weight binge eaters. Am J Gastroenterol 1994;89:387-391.
- Levy RL, Linde JA, Feld KA, et al. The association of gastrointestinal symptoms with weight, diet, and exercise in weight-loss program participants. Clin Gastroenterol Hepatol 2005;3:992-996.
- Abraham S, Kellow JE. Do the digestive tract symptoms in eating disorder patients represent functional gastrointestinal disorders? BMC Gastroenterol 2013;13:38.
- Dejong H, Perkins S, Grover M, et al. The prevalence of irritable bowel syndrome in outpatients with bulimia nervosa. Int J Eat Disord 2011;44:661-664.
- Benini L, Todesco T, Frulloni L, et al. Esophageal motility and symptoms in restricting and binge-eating/purging anorexia. Dig Liver Dis 2010;42:767-772.
- Ochi M, Tominaga K, Iketani T, et al. Perfectionism underlying psychological background correlated with the symptoms of functional dyspepsia. J Gastroenterol 2008;43:699-704.
- Lipowski ZJ. Somatization: the concept and its clinical application. Am J Psychiatry 1988;145:1358-1368.
- Dimsdale JE, Creed F, Escobar J, et al. Somatic symptom disorder: An important change in DSM. J Psychosom Res 2013;75:223-228.
- Duddu V, Isaac MK, Chaturvedi SK. Somatization, somatosensory amplification, attribution styles and illness behaviour: a review. Int Rev Psychiatry 2006;18:25-33.
- MacLean EW, Palsson OS, Turner MJ, et al. Development and validation of new disease-specific measures of somatization and comorbidity in IBS. J Psychosom Res 2012;73:351-355.
- Wilhelmsen I. Somatization, sensitization, and functional dyspepsia. Scand J Psychol 2002;43:177-180.
- Whitehead WE, Palsson OS, Levy RR, et al. Comorbidity in irritable bowel syndrome. Am J Gastroenterol 2007;102:2767-2776.
- Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology 2002;122:1140-1156.
- Van Oudenhove L, Vandenberghe J, Vos R, et al. Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia. Psychosom Med 2011;73:648-655.
- Clauwaert N, Jones MP, Holvoet L, et al. Associations between gastric sensorimotor function, depression, somatization, and symptom-based subgroups in functional gastroduodenal disorders: are all symptoms equal? Neurogastroenterol Motil 2012;24:1088-e1565.
- Gathaiya N, Locke GR, 3rd, Camilleri M, et al. Novel associations with dyspepsia: a community-based study of familial aggregation, sleep dysfunction and somatization. Neurogastroenterol Motil 2009;21:922-e969.
- Van Oudenhove L, Vandenberghe J, Geeraerts B, et al. Determinants of symptoms in functional dyspepsia: Gastric sensorimotor function, psychosocial factors, or somatization? Gut 2008;57:1666-1673.
- Jones MP, Coppens E, Vos R, et al. A multidimensional model of psychobiological interactions in functional dyspepsia: A structural equation modelling approach. Gut 2013;62:1573-1580.
- Spiegel BM, Kanwal F, Naliboff B, et al. The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndrome. Am J Gastroenterol 2005;100:2262-2273.
- Porcelli P, Todarello O. Psychological factors in medical disorders assessed with the diagnostic criteria for psychosomatic research. Adv Psychosom Med 2012;32:108-117.
- Agosti V, Quitkin FM, Stewart JW, et al. Somatization as a predictor of medication discontinuation due to adverse events. Int Clin Psychopharmacol 2002;17:311-314.
- Kanaan RAA, Lepine JP, Wessely SC. The association or otherwise of the functional somatic syndromes. Psychosom Med 2007;69:855-859.
- Lackner JM, Ma CX, Keefer L, et al. Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2013;11:1147-1157.
- Spiegel B, Strickland A, Naliboff BD, et al. Predictors of patient-assessed illness severity in irritable bowel syndrome. Am J Gastroenterol 2008;103:2536-2543.
- Spiegel BM, Khanna D, Bolus R, et al. Understanding gastrointestinal distress: a framework for clinical practice. Am J Gastroenterol 2011;106:380-385.
- Chilcot J, Moss-Morris R. Changes in illness-related cognitions rather than distress mediate improvements in irritable bowel syndrome (IBS) symptoms and disability following a brief cognitive behavioural therapy intervention. Behav Res Ther 2013;51:690-695.
- Mearin F. Postinfectious functional gastrointestinal disorders. J Clin Gastroenterol 2011;45 Suppl:S102-105.
- Spiller R, Garsed K. Postinfectious irritable bowel syndrome. Gastroenterology 2009;136:1979-1988.
- Bennett EJ, Evans P, Scott AM, et al. Psychological and sex features of delayed gut transit in functional gastrointestinal disorders. Gut 2000;46:83-87.
- Amarnath RP, Abell TL, Malagelada JR. The rumination syndrome in adults. A characteristic manometric pattern. Ann Intern Med 1986;105:513-518.
- Sharma MP, Manjula M. Behavioural and psychological management of somatic symptom disorders: an overview. Int Rev Psychiatry 2013;25:116-124.
- Tyrer P, Cooper S, Tyrer H, et al. CHAMP: Cognitive behaviour therapy for health anxiety in medical patients, a randomised controlled trial. BMC Psychiatry 2011;11:99.
- Hedman E, Andersson E, Lindefors N, et al. Cost-effectiveness and long-term effectiveness of internet-based cognitive behaviour therapy for severe health anxiety. Psychol Med 2013;43:363-374.
- Labus JS, Bolus R, Chang L, et al. The Visceral Sensitivity Index: development and validation of a gastrointestinal symptom-specific anxiety scale. Aliment Pharmacol Ther 2004;20:89-97.
- Berrocal C, Moreno FR, Cano J. Anxiety sensitivity and panic symptomatology: the mediator role of hypochondriacal concerns. Span J Psychol 2007;10:159-166.
- Hadlandsmyth K, Rosenbaum DL, Craft JM, et al. Health care utilisation in patients with non-cardiac chest pain: a longitudinal analysis of chest pain, anxiety and interoceptive fear. Psychol Health 2013;28:849-861.
- Robertson N, Javed N, Samani NJ, et al. Psychological morbidity and illness appraisals of patients with cardiac and non-cardiac chest pain attending a rapid access chest pain clinic: a longitudinal cohort study. Heart 2008;94:e12.
- Bredenoord AJ, Weusten BL, Timmer R, et al. Psychological factors affect the frequency of belching in patients with aerophagia. Am J Gastroenterol 2006;101:2777-2781.
- Hazlett-Stevens H, Craske MG, Mayer EA, et al. Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety. J Psychosom Res 2003;55:501-505.
- Ljotsson B, Hesser H, Andersson E, et al. Mechanisms of change in an exposure-based treatment for irritable bowel syndrome. J Consult Clin Psychol 2013;81:1113-1126.
- Chapman S, Martin M. Attention to pain words in irritable bowel syndrome: increased orienting and speeded engagement. Br J Health Psychol 2011;16:47-60.
- Gibbs-Gallagher N, Palsson OS, Levy RL, et al. Selective recall of gastrointestinal-sensation words: evidence for a cognitive-behavioral contribution to irritable bowel syndrome. Am J Gastroenterol 2001;96:1133-1138.
- Posserud I, Svedlund J, Wallin J, et al. Hypervigilance in irritable bowel syndrome compared with organic gastrointestinal disease. J Psychosom Res 2009;66:399-405.
- White KS, Craft JM, Gervino EV. Anxiety and hypervigilance to cardiopulmonary sensations in non-cardiac chest pain patients with and without psychiatric disorders. Behav Res Ther 2010;48:394-401.
- Barsky AJ, Goodson JD, Lane RS, et al. The amplification of somatic symptoms. Psychosom Med 1988;50:510-519.
- Drossman DA, Patrick DL, Whitehead WE, et al. Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire. Am J Gastroenterol 2000;95:999-1007.
- Seres G, Kovacs Z, Kovacs A, et al. Different associations of health related quality of life with pain, psychological distress and coping strategies in patients with irritable bowel syndrome and inflammatory bowel disorder. J Clin Psychol Med Settings 2008;15:287-295.
- Piche M, Bouin M, Arsenault M, et al. Decreased pain inhibition in irritable bowel syndrome depends on altered descending modulation and higher-order brain processes. Neuroscience 2011;195:166-175.
- Ng SM, Chow KW. Symptoms catastrophizing versus social hypervigilance in irritable bowel syndrome patients. Soc Work Health Care 2012;51:743-756.
- Lackner J, Jaccard J, Baum C, et al. Patient-reported outcomes for irritable bowel syndrome are associated with patients’ severity ratings of gastrointestinal symptoms and psychological factors. Clin Gastroenterol Hepatol 2011;9:957-964.
- Zhao Y, Ke M, Wang Z, et al. Pathophysiological and psychosocial study in patients with functional vomiting. J Neurogastroenterol Motil 2010;16:274-280.
- Tayama J, Nakaya N, Hamaguchi T, et al. Effects of personality traits on the manifestations of irritable bowel syndrome. Biopsychosoc Med 2012;6:20.
- Deary IJ, Wilson JA, Mitchell L, et al. Covert psychiatric disturbance in patients with globus pharyngis. Br J Med Psychol 1989;62 ( Pt 4):381-389.
- Farnam A, Somi MH, Sarami F, et al. Five personality dimensions in patients with irritable bowel syndrome. Neuropsychiatr Dis Treat 2008;4:959-962.
- Zobel A, Barkow K, Schulze-Rauschenbach S, et al. High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic-pituitary-adrenocortical system in healthy volunteers. Acta Psychiatr Scand 2004;109:392-399.
- Talley NJ, Boyce PM, Jones M. Is the association between irritable bowel syndrome and abuse explained by neuroticism? A population-based study. Gut 1998;42:47-53.
- Jess P, Eldrup J. The personality patterns in patients with duodenal ulcer and ulcer-like dyspepsia and their relationship to the course of the diseases. Hvidovre Ulcer Project Group. J Intern Med 1994;235:589-594.
- Laceulle OM, Ormel J, Aggen SH, et al. Genetic and environmental influences on the longitudinal structure of neuroticism: a trait-state approach. Psychol Sci 2013;24:1780-1790.
- Costa PT, Jr., McCrae RR. Overview: innovations in assessment using the revised NEO personality inventory. Assessment 2000;7:325-327.
- Sararoudi RB, Afshar H, Adibi P, et al. Type D personality and quality of life in patients with irritable bowel syndrome. J Res Med Sci 2011;16:985-992.
- Hansel SL, Umar SB, Lunsford TN, et al. Personality traits and impaired health-related quality of life in patients with functional gastrointestinal disorders. Clin Gastroenterol Hepatol 2010;8:220-222.
- Han M, Duan LP, Huang YQ, et al. Personality traits in patients referred for functional dyspepsia. Zhonghua Nei Ke Za Zhi 2010;49:997-1001.
- Kano M, Hamaguchi T, Itoh M, et al. Correlation between alexithymia and hypersensitivity to visceral stimulation in human. Pain 2007;132:252-263.
- Kano M, Fukudo S. The alexithymic brain: the neural pathways linking alexithymia to physical disorders. Biopsychosoc Med 2013;7:1.
- Makino S, Jensen MP, Arimura T, et al. Alexithymia and chronic pain: the role of negative affectivity. Clin J Pain 2013;29:354-361.
- White KS, McDonnell CJ, Gervino EV. Alexithymia and anxiety sensitivity in patients with non-cardiac chest pain. J Behav Ther Exp Psychiatry 2011;42:432-439.
- Faramarzi M, Shokri-Shirvani J, Kheirkhah F. The role of psychiatric symptoms, alexithymia, and maladaptive defenses in patients with functional dyspepsia. Indian J Med Sci 2012;66:40-48.
- Henningsen P, Zimmermann T, Sattel H. Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review. Psychosom Med 2003;65:528-533.
- Henningsen P, Herzog W. Irritable bowel syndrome and somatoform disorders. J Psychosom Res 2008;64:625-629.
- Van Oudenhove L, Aziz Q. The role of psychosocial factors and psychiatric disorders in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013;10:158-167.
- Mayer EA, Tillisch K. The brain-gut axis in abdominal pain syndromes. Annu Rev Med 2011;62:381-396.
- Fields H. State-dependent opioid control of pain. Nat Rev Neurosci 2004;5:565-575.
- Wilder-Smith CH. The balancing act: endogenous modulation of pain in functional gastrointestinal disorders. Gut 2011;60:1589-1599.
- Mayer EA, Naliboff BD, Craig ADB. Neuroimaging of the brain-gut axis: From basic understanding to treatment of functional GI disorders. Gastroenterology 2006;131:1925-1942.
- Van Oudenhove L. Understanding gut–brain interactions in gastrointestinal pain by neuroimaging: lessons from somatic pain studies. Neurogastroenterol Motil 2011;23:292-302.
- Klossika I, Flor H, Kamping S, et al. Emotional modulation of pain: a clinical perspective. Pain 2006;124:264-268.
- Wiech K, Tracey I. The influence of negative emotions on pain: behavioral effects and neural mechanisms. Neuroimage 2009;47:987-994.
- Coen SJ, Yaguez L, Aziz Q, et al. Negative mood affects brain processing of visceral sensation. Gastroenterology 2009;137:253-261.
- Rosenberger C, Elsenbruch S, Scholle A, et al. Effects of psychological stress on the cerebral processing of visceral stimuli in healthy women. Neurogastroenterol Motil 2009;21:740-e745.
- Weltens N, Schaub N, Ly HG, et al. Positive and negative emotion modulate esophageal pain perception in health. Neurogastroenterol Motil 2013;25:11.
- Palit S, Sheaff RJ, France CR, et al. Serotonin transporter gene (5-HTTLPR) polymorphisms are associated with emotional modulation of pain but not emotional modulation of spinal nociception. Biol Psychol 2011;86:360-369.
- Horjales-Araujo E, Demontis D, Lund EK, et al. Emotional modulation of muscle pain is associated with polymorphisms in the serotonin transporter gene. Pain 2013;154:1469-1476.
- Rhudy JL, DelVentura JL, Terry EL, et al. Emotional modulation of pain and spinal nociception in fibromyalgia. Pain 2013;154:1045-1056.
- Coen SJ, Kano M, Farmer AD, et al. Neuroticism influences brain activity during the experience of visceral pain. Gastroenterology 2011;141:909-917.
- Farmer AD, Coen SJ, Kano M, et al. Psychophysiological responses to pain identify reproducible human clusters. Pain 2013;154:2266-2276.
- Farmer AD, Coen SJ, Kano M, et al. Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters. Neurogastroenterol Motil 2013;26:139-148.
- Wiech K, Ploner M, Tracey I. Neuriocognitive aspects of pain perception. Trends Cogn Sci 2008;12:306-313.
- Coen SJ, Aziz Q, Yaguez L, et al. Effects of attention on visceral stimulus intensity encoding in the male human brain. Gastroenterology 2008;135:2065-2074.
- Kennedy PJ, Clarke G, Quigley EMM, et al. Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome. Neurosci Biobehav Rev 2012;36:310-340.
- Kaptchuk TJ, Kelley JM, Conboy LA, et al. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ 2008;336:999-1003.
- Elsenbruch S, Schmid J, Basler M, et al. How positive and negative expectations shape the experience of visceral pain: an experimental pilot study in healthy women. Neurogastroenterol Motil 2012;24:914-e460.
- Schmid J, Theysohn N, Gass F, et al. Neural mechanisms mediating positive and negative treatment expectations in visceral pain: A functional magnetic resonance imaging study on placebo and nocebo effects in healthy volunteers. Pain 2013;154:2372-2380.
- Elsenbruch S, Kotsis V, Benson S, et al. Neural mechanisms mediating the effects of expectation in visceral placebo analgesia: An fMRI study in healthy placebo responders and nonresponders. Pain 2012;153:382-390.
- Craske MG, Wolitzky-Taylor KB, Labus J, et al. A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations. Behav Res Ther 2011;49:413-421.
- Yaguez L, Coen S, Gregory LJ, et al. Brain response to visceral aversive conditining: A functional magnetic resonance imagine study. Gastroenterology 2005;128:1819-1829.
- Kattoor J, Gizewski ER, Kotsis V, et al. Fear conditioning in an abdominal pain model: neural responses during associative learning and extinction in healthy subjects. PLoS One 2012;8:e51149.
- Kattoor J, Thurling M, Gizewski E, et al. Cerebellar contributions to different phases of visceral aversive extinction learning. Cerebellum 2013;13:1-8.
- Merskey HM, Bogduk N. Classification of chronic pain: Descriptions of chronic pain syndromes and definition of pain terms. Seattle: IASP Press, 1994.
- Elsenbruch S, Rosenberger C, Enck P, et al. Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study. Gut 2010;59:489-495.
- Berman SM, Naliboff BD, Suyenobu B, et al. Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome. J Neurosci 2008;28:349-359.
- Chang L. The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome. Gastroenterology 2011;140:761-765.
- Elsenbruch S. Abdominal pain in irritable bowel syndrome: a review of putative psychological, neural and neuro-immune mechanisms. Brain Behav Immun 2011;25:386-394.
- Posserud I, Agerforz P, Ekman R, et al. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004;53:1102-1108.
- Dickhaus B, Mayer EA, Firooz N, et al. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am J Gastroenterol 2003;98:135-143.
- Dorn SD, Palsson OS, Thiwan SIM, et al. Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity. Gut 2007;56:1202-1209.
- Naliboff BD, Munakata J, Fullerton S, et al. Evidence for two distinct percetual alterations in irritable bowel syndrome. Gut 1997;41:505-512.
- Tillisch K, Mayer EA, Labus JS. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology 2011;140:91-100.
- Lorenz J, Tracey I. Brain correlates of psychological amplification of pain. In: Mayer EA, Bushnell DM, eds. Functional pain syndromes: Presentation and pathophysiology. Seattle: IASP Press, 2009:385-404.
- Mayer EA, Aziz Q, Coen S, et al. Brain imaging approaches to the study of functional GI disorders: A Rome working team report. Neurogastroenterol Motil 2009;21:579-596.
- Larsson MB, Tillisch K, Craig AD, et al. Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome. Gastroenterology 2012;142:463-472 e463.
- Tillisch K, Labus JS. Advances in imaging the brain-gut axis: functional gastrointestinal disorders. Gastroenterology 2011;140:407-411 e401.
- Labus JS, Mayer EA, Jarcho J, et al. Acute tryptophan depletion alters the effective connectivity of emotional arousal circuitry during visceral stimuli in healthy women. Gut 2011;60:1196-1203.
- Mayer EA, Berman S, Suyenobu B, et al. Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis. Pain 2005;115:398-409.
- Labus JS, Naliboff BD, Berman SM, et al. Brain networks underlying perceptual habituation to repeated aversive visceral stimuli in patients with irritable bowel syndrome. Neuroimage 2009;47:952-960.
- Seminowicz DA, Labus JS, Bueller JA, et al. Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology 2010;139:48-57.e42.
- Blankstein U, Chen J, Diamant NE, et al. Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors. Gastroenterology 2010;138:1783-1789.
- Letzen JE, Craggs JG, Perlstein WM, et al. Functional connectivity of the default mode network and its association with pain networks in irritable bowel patients assessed via lidocaine treatment. J Pain 2013;14:1077-1087.
- Hong JY, Kilpatrick LA, Labus J, et al. Patients with chronic visceral pain show sex-related alterations in intrinsic oscillations of the resting brain. J Neurosci 2013;33:11994-12002.
- Ellingson BM, Mayer E, Harris RJ, et al. Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. Pain 2013;154:1528-1541.
- Chen JY, Blankstein U, Diamant NE, et al. White matter abnormalities in irritable bowel syndrome and relation to individual factors. Brain Res 2011;1392:121-131.
- Ly H, Ceccarini J, Weltens N, et al. Increased cerebral cannabinoid-1 receptor availability is a stable feature of functional dyspepsia: a [18F] ML-9470 PET study. Psychother Psychosom 2015;84:149-158.
- Vanheel H, Farre R. Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013;10:142-149.
- Vandenberghe J, Dupont P, Van Oudenhove L, et al. Regional cerebral blood flow during gastric balloon distention in functional dyspepsia. Gastroenterology 2007;132:1684-1693.
- Van Oudenhove L, Vandenberghe J, Dupont P, et al. Abnormal regional brain acticity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H215O-PET study. Am J Gastroenterol 2010;105:913-924.
- Van Oudenhove L, Labus J, Dupont P, et al. Altered brain network connectivity associated with increased perceptual response to aversive gastric distension and its expectation in functional dyspepsia. Neurogastroenterol Motil 2010;22:20-21.
- Van Oudenhove L, Vandenberghe J, Dupont P, et al. Regional brain activity in functional dyspepsia: a H2150-PET study on the role of gastric sensitivity & abuse history. Gastroenterology 2010;139:36-47.
- Van Oudenhove L, Labus JS, Dupont P, et al. Altered brain connectivity underlies visceral perceptual hypersensitivity in abused functional dyspepsia patients. Gastroenterology 2012;142:S69-S70.
- Zeng F, Qin W, Liang F, et al. Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity. Gastroenterology 2011;141:499-506.
- Liu MI, Liang FR, Zeng F, et al. Cortical-limbic regions modulate depression and anxiety factors in functional dyspepsia: A PET-CT study. Ann Nucl Med 2012;26:35-40.
- Liu P, Zeng F, Zhou G, et al. Alterations of the default mode network in functional dyspepsia patients: A resting-state fMRI study. Neurogastroenterol Motil 2013;25:e382-e388.
- Van Oudenhove L, Vandenberghe J, Dupont P, et al. Cortical deactivations during gastric fundus distension in health: Visceral pain-specific response or attenuation of ‘default mode’ brain function? A H215O-PET study. Neurogastroenterol Motil 2009;21:259-271.
- Liu P, Qin W, Wang J, et al. Identifying neural patterns of functional dyspepsia using multivariate pattern analysis: A resting-state fMRI study. PLoS One 2013;8:e68205.
- Nan J, Liu J, Li G, et al. Whole-brain functional connectivity identification of functional dyspepsia. PLoS One 2013;8:e65870.
- Zhou G, Liu P, Wang J, et al. Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study. Magn Res Imaging 2013;31:996-1000.
- Zeng F, Qin W, Yang Y, et al. Regional brain structural abnormality in meal-related functional dyspepsia patients: A voxel-based morphometry study. PLoS One 2013;8:e68383.
- Zhou G, Qin W, Zeng F, et al. White-matter microstructural changes in functional dyspepsia: A diffusion tensor imagine study. Am J Gastroenterol 2013;108:260-269.
- Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut 2000;47:861-869.
- Tache Y, Bonaz B. Corticotropin-releasing factor receptors and stress-related alterations of gut motor function. J Clin Invest 2007;117:33-40.
- Kiank C, Tache Y, Larauche M. Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: Role of corticotropin-releasing factor receptors. Brain Behav Immun 2010;24:41-48.
- Stengel A, Tache Y. Corticotropin-releasing factor signaling and visceral response to stress. Exp Biol Med 2010;235:1168-1178.
- Hyman SE. How adversity gets under the skin. Nat Neurosci 2009;12:241-243.
- Bradley LA, Richter JE, Pulliam TJ, et al. The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors. Am J Gastroenterol 1993;88:11-19.
- Blondeau K, Pauwels A, Boecxstaens V, et al. Affective disorders, somatization and body awareness are associated with positive symptom association during 24 hour impedance-pH monitoring in patients with reflux symptoms. Gastroenterology 2012;241:S204.
- Farre R. Pathophysiology of gastro-esophageal reflux disease: a role for mucose integrity? Neurogastroenterol Motil 2013;25:783-799.
- Geeraerts B, Vandenberghe J, Van Oudenhove L, et al. Influence of experimientally induced anxiety on gastric sensorimotor function in man. Gastroenterology 2005;129:1437-1444.
- Weltens N, Ly HG, Vos R, et al. State anxiety & co-morbid generalized anxiety disorder are associated with impaired gastric accommodation in functional dyspepsia. Neurogastroenterol Motil 2013;25:11-12.
- Vanheel H, Vicario M, Vanuytsel T, et al. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut 2015:Epub ahead of print.
- Kellow JE, Gill RC, Wingate DL. Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 1990;98:1208-1218.
- Kellow JE, Langeluddecke PM, Eckersley GM, et al. Effects of acute psychologic stress on small-intestinal motility in health and the irritable bowel syndrome. Scand J Gastroenterol 1992;27:53-58.
- Kellow JE, Phillips SF. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987;92:1885-1893.
- Kellow JE, Eckersley CM, Jones MP. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991;101:1621-1627.
- Kellow JE, Phillips SF, Miller LJ, et al. Dysmotility of the small intestine in irritable bowel syndrome. Gut 1988;29:1236-1243.
- Cogliandro RF, Antonucci A, De Giorgio R, et al. Patient-reported outcomes and gut dysmotility in functional gastrointestinal disorders. Neurogastroenterol Motil 2011;23:1084-1091.
- Evans PR, Bennett EJ, Bak YT, et al. Jejunal sensorimotor dysfunction in irritable bowel syndrome: Clinical and psychosocial features. Gastroenterology 1996;110:393-404.
- Kellow JE, Eckersley GM, Jones M. Enteric and central contributions to intestinal dysmotility in irritable bowel syndrome. Dig Dis Sci 1992;37:168-174.
- Kumar D, Wingate DL. The irritable bowel syndrome: a paroxysmal motor disorder. Lancet 1985;326:973-977.
- Cann PA, Read NW, Cammack J, et al. Psychological stress and the passage of a standard meal through the stomach and small intestine in man. Gut 1983;24:236-240.
- Lindfors P, Tornblom H, Sadik R, et al. Effects on gastrointestinal transit and antroduodenojejunal manometry after gut-directed hypnotherapy in irritable bowel syndrome (IBS). Scand J Gastroenterol 2012;47:1480-1487.
- Tornblom H, Van Oudenhove L, Sadik R, et al. Colonic transit time and IBS symptoms: What’s the link? Am J Gastroenterol 2012;107:754-760.
- Kanazawa M, Palsson OS, Thiwan SIM, et al. Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits. Am J Gastroenterol 2008;103:2550-2561.
- Matricon J, Meleine M, Gelot A, et al. Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome. Aliment Pharmacol Ther 2012;36:1009-1031.
- O’Malley D, Quigley EMM, Dinan TG, et al. Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome? Brain Behav Immun 2011;25:1333-1341.
- Matteoli G, Boeckxstaens GE. The vagal innervation of the gut and immune homeostasis. Gut 2013;62:1214-1222.
- Dinan TG, Quigley EM, Ahmed SM, et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006;130:304-311.
- Liebregts T, Adam B, Bredack C, et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 2007;132:913-920.
- Kindt S, Van Oudenhove L, Broekaert D, et al. Immune dysfunction in patients with functional gastrointestinal disorders. Neurogastroenterol Motil 2009;21:389-398.
- Piche T, Saint-Paul MC, Dainese R, et al. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome. Gut 2008;57:468-473.
- Vanuytsel T, van Wanrooy S, Vanheel H, et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 2013:Epub ahead of print.
- Tougas G. The autonomic nervous system in functional bowel disorders. Gut 2000;47 Suppl 4:iv78-80; discussion iv87.
- Mazurak N, Seredyuk N, Sauer H, et al. Heart rate variability in the irritable bowel syndrome: a review of the literature. Neurogastroenterol Motil 2012;24:206-216.
- Liu Q, Wang EM, Yan XJ, et al. Automatic functioning in irritable bowel syndrome as measured by heart rate variability: A meta-analysis. J Dig Dis 2013;14:638-646.
- Tak LM, Riese H, de Bock GH, et al. As good as it gets? A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders. Biol Psychol 2009;82:101-110.
- Tillisch K, Mayer EA, Labus JS, et al. Sex specific alterations in autonomic function among patients with irritable bowel syndrome. Gut 2005;54:1396-1401.
- Mazur M, Furgala A, Jablonski K, et al. Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients. Med Sci Monit 2012;18:CR493-499.
- Heitkemper M, Jarrett M, Bond EF, et al. Impact of sex and gender on irritable bowel syndrome. Biol Res Nurs 2003;5:56-65.
- Suarez-Hitz KA, Otto B, Bidlingmaier M, et al. Altered psychobiological responsiveness in women with irritable bowel syndrome. Psychosom Med 2012;74:221-231.
- Heitkemper MM, Cain KC, Deechakawan W, et al. Anticipation of public speaking and sleep and the hypothalamic-pituitary-adrenal axis in women with irritable bowel syndrome. Neurogastroenterol Motil 2012;24:626-631.
- Chang L, Sundaresh S, Elliott J, et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 2009;21:149-159.
- Tak LM, Cleare AJ, Ormel J, et al. Meta-analysis and meta-regression of hypothalamic-pituitary-adrenal axis activity in functional somatic disorders. Biol Psychol 2011;87:183-194.
- Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012;13:701-712.
- Aziz Q, Dore J, Emmanuel A, et al. Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil 2013;25:4-15.
- Tana C, Umesaki Y, Imaoka A, et al. Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterol Motil 2010;22:512-519, e114-515.
- Clarke G, Cryan JF, Dinan TG, et al. Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria. Aliment Pharmacol Ther 2012;35:403-413.
- Jalanka-Tuovinen J, Salonen A, Nikkila J, et al. Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One 2011;6:e23035.
- Tillisch K, Labus J, Kilpatrick L, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013;144:1394-1401.
- Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A 2011;108:16050-16055.
- Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother 2012;12:577-585.
- Lewis GN, Rice DA, McNair PJ. Conditioned pain modulation in populations with chronic pain: a systematic review and meta-analysis. J Pain 2012;13:936-944.
- Heymen S, Maixner W, Whitehead WE, et al. Central processing of noxious somatic stimuli in patients with irritable bowel syndrome compared with healthy controls. Clin J Pain 2010;26:104-109.
- Von Korff M, Moore JC. Stepped care for back pain: Activating approaches for primary care. Ann Intern Med 2001;134:911-917.
- Gelenberg A. Depression is still underrecognized and undertreated. Arch Intern Med 1999;159:1657-1658.
- van Tilburg MA, Chitkara DK, Palsson OS, et al. Parental worries and beliefs about abdominal pain. J Pediatr Gastroenterol Nutr 2009;48:311-317.
- Claar RL, Guite JW, Kaczynski KJ, et al. Factor structure of the Adult Responses to Children’s Symptoms: validation in children and adolescents with diverse chronic pain conditions. Clin J Pain 2010;26:410-417.
- Bjelland I, Dahl AA, Haug TT, et al. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002;52:69-77.
- Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361-370.
- Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001;16:606-613.
- Spitzer RL, Kroenke K, Williams JBW, et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006;166:1092-1097.
- Kroenke K, Spitzer RL, Williams JB. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med 2002;64:258-266.
- Garber J, Walker LS, Zeman J. Somatization symptoms in a community sample of children and adolescents: Further validation of the Children’s Somatization Inventory. Psychol Assess 1991;3:588-595.
- Spitzer RL, Williams JB, Kroenke K, et al. Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. JAMA 1994;272:1749-1756.
- Moss-Morris R, Weinman J, Petrie K, et al. The revised illness perception questionnaire (IPQ-R). Psychol Health 2002;17:1-16.
- Labus JS, Mayer EA, Chang L, et al. The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index. Psychosom Med 2007;69:89-98.
- Kerns R, Southwick S, Giller E, et al. The relationship between reports of pain-related social interactions and expressions of pain and affective distress. Behav Ther 1991;22:101-111.
- Kerns RD, Haythornthwaite J, Rosenberg R, et al. The Pain Behavior Check List (PBCL): factor structure and psychometric properties. J Behav Med 1991;14:155-167.
- Goubert L, Eccleston C, Vervoort T, et al. Parental catastrophizing about their child’s pain. The parent version of the Pain Catastrophizing Scale (PCS-P): a preliminary validation. Pain 2006;123:254-263.
- Keefe FJ, Brown GK, Wallston KA, et al. Coping with rheumatoid arthritis pain: catastrophizing as a maladaptive strategy. Pain 1989;37:51-56.
- Shin LM, McNally RJ, Kosslyn SM, et al. A positron emission tomographic study of symptom provocation in PTSD. Ann N Y Acad Sci 1997;821:521-523.
- Eisen GM, Locke GR, 3rd, Provenzale D. Health-related quality of life: a primer for gastroenterologists. Am J Gastroenterol 1999;94:2017-2021.
- Patrick DL, Drossman DA, Frederick IO, et al. Quality of life in persons with irritable bowel syndrome: Development and validation of a new measure. Dig Dis Sci 1998;43:400-411.
- Walker LS, Greene JW. The functional disability inventory: measuring a neglected dimension of child health status. J Pediatr Psychol 1991;16:39-58.
- Sarason IG, Johnson JH, Siegel JM. Assessing the impact of life changes: development of the Life Experiences Survey. J Consult Clin Psychol 1978;46:932-946.
- Brown GW. Social origins of depression: A study of psychiatric disorder in women. London: Tavistock, 1978.
- Kohn PM, Lafreniere K, Gurevich M. Hassles, health, and personality. J Pers Soc Psychol 1991;61:478-482.
- Garrett VD, Brantley PJ, Jones GN, et al. The relation between daily stress and Crohn’s disease. J Behav Med 1991;14:87-96.
- Jenkins CD, Hurst MW, Rose RM. Life changes. Do people really remember? Arch Gen Psychiatry 1979;36:379-384.
- Levenstein S, Prantera C, Varvo V, et al. Development of the Perceived Stress Questionnaire: A new tool for psychosomatic research. J Psychosom Res 1993;37:19-32.
- Sprague S, Goslings JC, Hogentoren C, et al. Prevalence of intimate partner violence across medical and surgical health care settings: a systematic review. Violence Against Women 2014;20:118-136.
- Drossman DA, Talley NJ, Leserman J, et al. Sexual and physical abuse and gastrointestinal illness. Review and recommendations. Ann Intern Med 1995;123:782-794.
- Friedman S. On the “true-false” memory syndrome: the problem of clinical evidence. Am J Psychother 1997;51:102-122.
- Drossman DA, Leserman J, Nachman G, et al. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 1990;113:828-833.
- Allen JG, Huntoon J, Evans RB. A self-report measure to screen for trauma history and its application to women in inpatient treatment for trauma-related disorders. Bull Menninger Clin 1999;63:429-442.
- Thabrew H, de Sylva S, Romans SE. Evaluating childhood adversity. Adv Psychosom Med 2012;32:35-57.
- Leserman J, Drossman DA, Li Z. The reliability and validity of a sexual and physical abuse history questionnaire in female patients with gastrointestinal disorders. Behav Med 1995;21:141-150.
- Bremner JD, Bolus R, Mayer EA. Psychometric properties of the early trauma inventory- self report. J Nerv Ment Dis 2007;195:211-218.
- Hooper L, Stockton P, Krupnick J, et al. Development, use, and psychometric properties of the Trauma History Questionnaire. J Loss Trauma 2011;16:258-283.
- Weiss DS, Marmar CR. The Impact of Event Scale-Revised. In: Wilson J, Keane TM, eds. Assessing psychological trauma and PTSD. New York: Guilford, 1996:399-411.
- Ippen CG, Ford J, Racusin R, et al. Traumatic Events Screening Inventory—Parent Report Revised. In: U.S. Department of Veterans Affairs NCfP, ed. Hanover, NH: U.S. Department of Veterans Affairs, National Center for PTSD, 2002.
- Fletcher K. Psychometric review of Dimensions of Stressful Events (DOSE) Ratings Scale. In: Stamm BH, ed. Measurement of stress, trauma, and adaptation. Lutherville, MD: Sidran Press, 1996:144-151.
- Lowe B, Grafe K, Kroenke K, et al. Predictors of psychiatric comorbidity in medical outpatients. Psychosom Med 2003;65:764-770.
- Derogatis LR, Melisaratos N. The Brief Symptom Inventory: an introductory report. Psychol Med 1983;13:595-605.
- Derogatis LR. Brief Symptom Inventory (BSI) 18: Administration, scoring, and procedures manual. Minneapolis: NCS Pearson, 2000.
- Kroenke K, Spitzer RL, Williams JB, et al. Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment. Arch Fam Med 1994;3:774-779.
- Pilowsky I. Dimensions of hypochondriasis. Br J Psychiatry 1967;113:89-93.
- Pilowsky I, Bassett D, Barrett R, et al. The illness behavior assessment schedule: Reliability and validity. Int J Psychiatry Med 1983;13:11-28.
- Speckens AE, Spinhoven P, Sloekers PP, et al. A validation study of the Whitely Index, the Illness Attitude Scales, and the Somatosensory Amplification Scale in general medical and general practice patients. J Psychosom Res 1996;40:95-104.
- Toner BB, Stuckless N, Ali A, et al. The development of a cognitive scale for functional bowel disorders. Psychosom Med 1998;60:492-497.
- Drossman DA, Toner BB, Whitehead WE, et al. Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003;125:19-31.
- Ware JE, Jr., Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473-483.
- Bijkerk CJ, de Wit NJ, Muris JW, et al. Outcome measures in irritable bowel syndrome: comparison of psychometric and methodological characteristics. Am J Gastroenterol 2003;98:122-127.
- Irvine EJ. Measuring quality of life: a review. Scand J Gastroenterol Suppl 1996;221:5-7.
- Chassany O, Marquis P, Scherrer B, et al. Validation of a specific quality of life questionnaire for functional digestive disorders. Gut 1999;44:527-533.
- Talley NJ, Fullerton S, Junghard O, et al. Quality of life in patients with endoscopy-negative heartburn: Reliability and sensitivity of disease-specific instruments. Am J Gastroenterol 2001;96:1998-2004.
- Van Slyke DA, Walker LS. Mothers’ responses to children’s pain. Clin J Pain 2006;22:387-391.
- Walker LS, Levy RL, Whitehead WE. Validation of a measure of protective parent responses to children’s pain. Clin J Pain 2006;22:712-716.
- Zolotor AJ, Runyan DK, Dunne MP, et al. ISPCAN Child Abuse Screen Tool Children’s Version (ICAST-C): Instrument development and multi-national pilot testing. Child Abuse Negl 2009;33:833-841.
- Runyan DK, Dunne MP, Zolotor AJ, et al. The development and piloting of the ISPCAN Child Abuse Screening Tool-Parent Version (ICAST-P). Child Abuse Negl 2009;33:826-832.
- March JS, Parker JD, Sullivan K, et al. The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity. J Am Acad Child Adolesc Psychiatry 1997;36:554-565.
- Kovacs M. The Children’s Depression Inventory: A self-rated depression scale for school-aged youngsters. Unpublished Manuscript. Pittsburgh: University of Pittsburgh, 1982.
- Walker LS, Smith CA, Garber J, et al. Development and validation of the Pain Response Inventory for children. Psychol Assess 1997;9:392-405.
- World Health Organization. World Health Organization schedules for clinical assessment in neuropsychiatry: American Psychiatric Association Press, Inc 1994.
- American Psychiatric Association. Diagnostic and statistical manual of mental disorders Washington, D.C.: American Psychiatric Association, 1994.
- American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Arlington, VA: American Psychiatric Publishing, 2013.
- Helzer JE, Robins LN. The diagnostic interview schedule: its development, evolution, and use. Soc Psychiatry Psychiatr Epidemiol 1988;23:6-16.
- Spitzer RL, Williams JB, Gibbon M, et al. The structured clinical interview for DSM-III-R (SCID). I: History, rationale, and description. Arch Gen Psychiatry 1992;49:624-629.
- First MB, Spitzer RL, Gibbon M, et al. User’s guide for the structured clinical interview for DSM-IV Axis I Disorders: SCID-I clinican version. Washington, D.C.: American Psychiatric Press, 1997.
- Wittchen HU. Reliability and validity studies of the WHO—Composite International Diagnostic Interview (CIDI): A critical review. J Psychiatr Res 1994;28:57-84.
- Kessler RC, Ustun TB. The World Mental Health (WMH) survey initiative version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res 2004;13:93-121.
- Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59 Suppl 20:22-33;quiz 34-57.
- Guthrie E, Creed FH, Whorwell PJ. Severe sexual dysfunction in women with the irritable bowel syndrome: comparison with inflammatory bowel disease and duodenal ulceration. BMJ 1987;295:577-578.
- Hurwicz ML, Berkanovic E. The stress process in rheumatoid arthritis. J Rheumatol 1993;20:1836-1844.
- Toner BB, Koyama E, Garfinkel PE, et al. Social desirability and irritable bowel syndrome. Int J Psychiatry Med 1992;22:99-103.
- Barnes PM, Bloom B, Nahin R. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report 2008;10:1-23.
- Harvey RF, Salih SY, Read AE. Organic and functional disorders in 2000 gastroenterology outpatients. Lancet 1983;1:632-634.
- Spiller R, Aziz Q, Creed F, et al. Guidelines on the irritable bowel syndrome: Mechanisms and practical management. Gut 2007;56:1770-1798.
- Drossman DA. Presidential address: Gastrointestinal illness and the biopsychosocial model. Psychosom Med 1998;60:258-267.
- Payne A, Blanchard EB. A controlled comparison of cognitive therapy and self-help support groups in the treatment of irritable bowel syndrome. J Consult Clin Psychol 1995;63:779-786.
- D’Zurilla TJ, Nezu AM. Problem-solving therapies. New York: Guilford Press, 2001.
- Nezu AM, Ronan GF. Life stress, current problems, problem solving, and depressive symptoms: an integrative model. J Consult Clin Psychol 1985;53:693-697.
- Chang C, Hui WM, Larn SK. Perceptual style and behavioral pattern of individuals with functional gastrointestinal disorders. Health Psychol 2000;19:146-154.
- Lackner JM, Jaccard J, Krasner SS, et al. Self-administered cognitive behavior therapy for moderate to severe irritable bowel syndrome: clinical efficacy, tolerability, feasibility. Clin Gastroenterol Hepatol 2008;6:899-906.
- Cheng C, Yang FC, Jun S, et al. Flexible coping psychotherapy for functional dyspeptic patients: a randomized, controlled trial. Psychosom Med 2007;69:81-88.
- Guthrie E, Creed F, Dawson D, et al. A controlled trial of psychological treatment for the irritable bowel syndrome. Gastroenterology 1991;100:450-457.
- Keefer L, Blanchard EB. The effects of relaxation response meditation on the symptoms of irritable bowel syndrome: results of a controlled treatment study. Behav Res Ther 2001;39:801-811.
- Boyce PM, Talley NJ, Balaam B, et al. A randomized controlled trial of cognitive behavior therapy, relaxation training, and routine clinical care for the irritable bowel syndrome. Am J Gastroenterol 2003;98:2209-2218.
- Rokicki LA, Holroyd KA, France CR, et al. Change mechanisms associated with combined relaxation/EMG biofeedback training for chronic tension headache. Appl Psychophysiol Biofeedback 1997;22:21-41.
- Fried R. Respiration in stress and stress control : Toward a theory of stress as a hypoxic phenomenon. In: Lehrer PM, Woolfolk RL, eds. Principles and practice of stress management. Second ed. New York: Guilford, 1993:301-331.
- Gaylord SA, Palsson OS, Garland EL, et al. Mindfulness training reduces the severity of irritable bowel syndrome in women: results of a randomized controlled trial. Am J Gastroenterol 2011;106:1678-1688.
- Kearney DJ, McDermott K, Martinez M, et al. Association of participation in a mindfulness programme with bowel symptoms, gastrointestinal symptom-specific anxiety and quality of life. Aliment Pharmacol Ther 2011;34:363-373.
- Lackner JM, Jaccard J, Baum C. Multidomain patient-reported outcomes of irritable bowel syndrome: Exploring person-centered perspectives to better understand symptom severity scores. Value Health 2013;16:97-103.
- McLaughlin KA, Nolen-Hoeksema S. Rumination as a transdiagnostic factor in depression and anxiety. Behav Res Ther 2011;49:186-193.
- Galovski TE, Blanchard EB. The treatment of irritable bowel syndrome with hypnotherapy. Appl Psychophysiol Biofeedback 1998;23:219-232.
- Whorwell PJ, Prior A, Faragher EB. Controlled trial of hypnotherapy in the treatment of severe refractory irritable bowel syndrome. Lancet 1984;324:1232-1234.
- Moser G, Tragner S, Gajowniczek EE, et al. Long-term success of GUT-directed group hypnosis for patients with refractory irritable bowel syndrome: A randomized controlled trial. Am J Gastroenterol 2013;108:602-609.
- Linden DEJ. How psychotherapy changes the brain—the contribution of functional neuroimaging. Mol Psychiatry 2006;11:528-538.
- Guthrie E. Brief psychotherapy with patients with refractory irritable bowel syndrome. Br J Psychother 1991;8:175-188.
- Lackner JM, Jaccard J, Krasner SS, et al. How does cognitive behavior therapy for irritable bowel syndrome work? A mediational analysis of a randomized clinical trial. Gastroenterology 2007;133:433-444.
- Mayer EA. Clinical practice. Irritable bowel syndrome. N Engl J Med 2008;358:1692-1699.
- Ford AC, Talley NJ, Schoenfeld PS, et al. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 2009;58:367-378.
- Lackner JM, Morley S, Mesmer C, et al. Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J Consult Clin Psychol 2004;72:1100-1113.
- Palsson OS, Whitehead WE. Psychological treatments in functional gastrointestinal disorders: A primer for the gastroenterologist. Clin Gastroenterol Hepatol 2013;11:208-216; quiz e222-203.
- McGrath PA. Pain in children: Nature, assessment, and treatment. New York: Guilford, 1990.
- Schwille IJD, Giel KE, Ellert U, et al. A community-based survey of abdominal pain prevalence, characteristics, and healthcare use among children. Clin Gastroenterol Hepatol 2009;7:1062-1068.
- Levy RL, van Tilburg MA. Functional abdominal pain in childhood: Background studies and recent research trends. Pain Res Manag 2012;17:413-417.
- Pajak R, Lackner J, Kamboj SK. A systematic review of minimal-contact psychological treatments for symptom management in irritable bowel syndrome. J Psychosom Res 2013;75:103-112.
- Kennedy TM, Chalder T, McCrone P, et al. Cognitive behavioural therapy in addition to antispasmodic therapy for irritable bowel syndrome in primary care: randomised controlled trial. Health Technol Assess 2006;10:1-67.
- Ljotsson B, Hedman E, Andersson E, et al. Internet-delivered exposure-based treatment vs. stress management for irritable bowel syndrome: a randomized trial. Am J Gastroenterol 2011;106:1481-1491.
- Heitkemper MM, Jarrett ME, Levy RL, et al. Self-management for women with irritable bowel syndrome. Clin Gastroenterol Hepatol 2004;2:585-596.
- Ahl A, Mikocka-Walus A, Gordon A, et al. Are self-administered or minimal therapist contact psychotherapies an effective treatment for irritable bowel syndrome (IBS): A systematic review. J Psychosom Res 2013;75:113-120.
- Sanders KA, Blanchard EB, Sykes MA. Preliminary study of a self-administered treatment for irritable bowel syndrome: comparison to a wait list control group. Appl Psychophysiol Biofeedback 2007;32:111-119.
- Jarrett ME, Cain KC, Burr RL, et al. Comprehensive self-management for irritable bowel syndrome: Randomized trial of in-person vs. combined in-person and telephone sessions. Am J Gastroenterol 2009;104:3004-3014.
- Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397-414.
- Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron 2007;55:377-391.
- Dharmshaktu P, Tayal V, Kalra BS. Efficacy of antidepressants as analgesics: a review. J Clin Pharmacol 2012;52:6-17.
- Moshiree B, Zhou Q, Price DD, et al. Central sensitisation in visceral pain disorders. Gut 2006;55:905-908.
- Gonsalkorale WM, Perrey C, Pravica V, et al. Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? Gut 2003;52:91-93.
- Tache Y, Martinez V, Million M, et al. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol 2001;280:G173-177.
- Pae CU, Masand PS, Ajwani N, et al. Irritable bowel syndrome in psychiatric perspectives: a comprehensive review. Int J Clin Pract 2007;61:1708-1718.
- Mahar I, Bambico FR, Mechawar N, et al. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav Rev 2014;38:173-192.
- Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 2008;11:1169-1180.
- Castren E. Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection. Mol Neurobiol 2004;29:289-302.
- Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006;59:1116-1127.
- Manji HK, Quiroz JA, Sporn J, et al. Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biol Psychiatry 2003;53:707-742.
- Dupin N, Mailliet F, Rocher C, et al. Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity. Neurotox Res 2006;10:193-198.
- Demir IE, Schafer KH, Tieftrunk E, et al. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals, and hypersensitivity. Acta Neuropathol 2013;125:491-509.
- Mawe GM, Strong DS, Sharkey KA. Plasticity of enteric nerve functions in the inflamed and postinflamed gut. Neurogastroenterol Motil 2009;21:481-491.
- Mercier A, Auger-Aubin I, Lebeau JP, et al. Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: An analysis of guidelines and systematic reviews. BMC Fam Pract 2013;14:55.
- O’Malley PG, Jackson JL, Santoro J, et al. Antidepressant therapy for unexplained symptoms and symptom syndromes. J Fam Pract 1999;48:980-990.
- Saarto T, Wiffen PJ. Antidepressants for neuropathic pain: A Cochrane review. J Neurol Neurosurg Psychiatry 2010;81:1372-1373.
- Salerno SM, Browning R, Jackson JL. The effect of antidepressant treatment on chronic back pain: A meta-analysis. Arch Intern Med 2002;162:19-24.
- Arnold LM, Keck PE, Jr., Welge JA. Antidepressant treatment of fibromyalgia. A meta-analysis and review. Psychosomatics 2000;41:104-113.
- Bryson HM, Wilde MI. Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. Drugs Aging 1996;8:459-476.
- Halpert A, Dalton CB, Diamant NE, et al. Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage. Am J Gastroenterol 2005;100:664-671.
- Max MB, Lynch SA, Muir J, et al. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326:1250-1256.
- Sindrup SH, Bjerre U, Dejgaard A, et al. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin Pharmacol Ther 1992;52:547-552.
- Moja PL, Cusi C, Sterzi RR, et al. Selective serotonin re-uptake inhibitors (SSRIs) for preventing migraine and tension-type headaches. Cochrane Database Syst Rev 2005;20:CD002919.
- Bomholt SF, Mikkelsen JD, Blackburn-Munro G. Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology 2005;48:252-263.
- Wattiez AS, Libert F, Privat AM, et al. Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain? Br J Pharmacol 2011;163:792-803.
- Greenbaum DS, Mayle JE, Vanegeren LE, et al. Effects of desipramine on irritable bowel syndrome compared with atropine and placebo. Dig Dis Sci 1987;32:257-266.
- Abdul-Baki H, El Hajj I, Elzahabi L, et al. A randomized controlled trial of imipramine in patients with irritable bowel syndrome. World J Gastroenterol 2009;15:3636-3642.
- Braak B, Klooker TK, Woulters MM, et al. Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsi, a double-blind placebo-controlled study. Aliment Pharmacol Ther 2011;34:638-648.
- Creed F. The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome. Gastroenterol 2003;124:303-317.
- Tabas G, Beaves M, Wang J, et al. Paroxetine to treat irritable bowel syndrome not responding to high-fiber diet: a double-blind, placebo-controlled trial. Am J Gastroenterol 2004;99:914-920.
- Masand PS, Pae CU, Krulewicz S, et al. A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome. Psychosomatics 2009;50:78-86.
- Vahedi H, Merat S, Rashidioon A, et al. The effect of fluoxetine in patients with pain and constipation-predominant irritable bowel syndrome: a double-blind randomized-controlled study. Aliment Pharmacol Ther 2005;22:381-385.
- Kuiken SD, Tytgat GN, Boeckxstaens GE. The selective serotonin reuptake inhibitor fluoxetine does not change rectal sensitivity and symptoms in patients with irritable bowel syndrome: a double blind, randomized, placebo-controlled study. Clin Gastroenterol Hepatol 2003;1:219-228.
- Tack J, Broekaert D, Fischler B, et al. A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome. Gut 2006;55:1095-1103.
- Talley NJ, Kellow JE, Boyce P, et al. Antidepressant therapy (imipramine and citalopram) for irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial. Dig Dis Sci 2008;53:108-115.
- Rahimi R, Nikfar S, Rezaie A, et al. Efficacy of tricyclic antidepressants in irritable bowel syndrome: a meta-analysis. World J Gastroenterol 2009;15:1548-1553.
- Ladabaum U, Sharabidze A, Levin TR, et al. Citalopram is not effective therapy for non-depressed patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2010;8:42.
- Jackson JL, O’Malley PG, Tomkins G, et al. Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am J Med 2000;108:65-72.
- Talley NJ, Locke GR, 3rd, Herrick LM, et al. Functional dyspepsia treatment trial (FDTT): a double-blind, randomized, placebo-controlled trial of antidepressants in functional dyspepsia, evaluating symptoms, psychopathology, pathophysiology and pharmacogenetics. Contemp Clin Trials 2012;33:523-533.
- Ruepert L, Quartero AO, de Wit NJ, et al. Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome. Cochrane Database Syst Rev 2011;10:CD003460.
- Brennan BP, Fogarty KV, Roberts JL, et al. Duloxetine in the treatment of irritable bowel syndrome: an open-label pilot study. Hum Psychopharmacol 2009;24:423-428.
- Vasile D, Vasiliu O, Tudor C, et al. Therapeutic efficacy of duloxetine versus selective serotonin reuptake inhibitors in irritable bowel syndrome. Eur Psychiatry 2011;26:1291.
- Van Kerkhoven LA, Laheij RJ, Aparicio N, et al. Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2008;6:746-752.
- Grover M, Dorn SD, Weinland SR, et al. Atypical antipsychotic quetiapine in the management of severe refractory functional gastrointestinal disorders. Dig Dis Sci 2009;54:1284-1291.
- Ly HG, Carbone F, Holvoet L, et al. Mirtazapine improves early satiation, nutrient intake, weight recovery and quality of life in functional dyspepsia with weight loss: a double-blind, randomized, placebo-controlled pilot study. Gastroenterology 2013;144:S-37.
- Tack J, Janssen P, Masaoka T, et al. Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clin Gastroenterol Hepatol 2012;10:1239-1245.
- Grover M, Camilleri M. Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases. J Gastroenterol 2013;48:177-181.
- Dekel R, Drossman DA, Sperber AD. The use of psychotropic drugs in irritable bowel syndrome. Expert Opin Investig Drugs 2013;22:329-339.
- Drossman DA. Beyond tricyclics: new ideas for treating patients with painful and refractory functional gastrointestinal symptoms. Am J Gastroenterol 2009;104:2897-2902.
- Clouse RE, Mayer EA, Aziz Q, et al. Functional abdominal pain syndrome. In: Drossman DA, Corazziari ES, Delvaux M, et al., eds. Rome III: The functional gastrointestinal disorders, 3rd ed. McLean, VA: Degnon Associates 2006:557-593.
- Svedlund J, Sjodin I, Ottosson J, et al. Controlled study of psychotherapy in irritable bowel syndrome. Lancet 1983;2:589-592.
- Keefer L, Blanchard EB. A one year follow-up of relaxation response meditation as a treatment for irritable bowel syndrome. Behav Res Ther 2002;40:541-546.
- Cassatly MG. Coaching the patient-physician relationship: a successful approach to lower healthcare costs with improved medical outcomes. J Med Pract Manage 2010;25:229-234.
- Kaplan SH, Greenfield S, Ware JE, Jr. Assessing the effects of physician-patient interactions on the outcomes of chronic disease. Med Care 1989; 27:10-27.
- Mawardi BH. Satisfactions, dissatisfactions, and causes of stress in medical practice. JAMA 1979;241:1483-1486.
- Owens DM, Nelson DK, Talley NJ. The irritable bowel syndrome: long-term prognosis and the physician-patient interaction. Ann Intern Med 1995;122:107-112.
- Pisano Gonzalez MM, Gonzalez Pisano A. Modifying habits and treatment adherence, essential for controlling the chronic disease. Enferm Clin 2013;24:59-66.
- Annandale EC. The malpractice crisis and the doctor-patient relationship. Sociol Health Illn 1989;11:1-23.
- Horowitz CR, Suchman AL, Branch WT, Jr., et al. What do doctors find meaningful about their work? Ann Intern Med 2003;138:772-775.
- Levinson W, Roter DL, Mullooly JP, et al. Physician-patient communication. The relationship with malpractice claims among primary care physicians and surgeons. JAMA 1997;277:553-559.
- Halpert A, Dalton CB, Palsson O, et al. Irritable bowel syndrome patients’ ideal expectations and recent experiences with healthcare providers: a national survey. Dig Dis Sci 2010;55:375-383.
- Drossman DA. Medicine has become a business, but what is the cost? Gastroenterology 2004;126:952-953.
- Smith S, Hanson JL, Tewksbury LR, et al. Teaching patient communication skills to medical students: A review of randomized controlled trials. Eval Health Prof 2007;30:3-21.
- Drossman DA. 2012 David Sun lecture: helping your patient by helping yourself—how to improve the patient-physician relationship by optimizing communication skills. Am J Gastroenterol 2013;108:521-528.
- Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav 1983;24:385-396.
- Zabora J, BrintzenhofeSzoc K, Jacobsen P, et al. A new psychosocial screening instrument for use with cancer patients. Psychosomatics 2001;42:241-246.
- Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385-401.
- Eaton WW, Muntaner C, Smith CA, et al. Center for Epidemiologic Studies Depression Scale: Review and revision (CESD and CESD-R). In: Maruish ME, ed. The use of psychological testing for treatment planning and outcomes assessment. 3rd ed. Mahwah, NJ: Lawrence Erlbaum, 2004:363-377.
- Gormally J, Black S, Daston S, et al. The assessment of binge eating severity among obese persons. Addict Behav 1982;7:47-55.
- Celio AA, Wilfley DE, Crow SJ, et al. A comparison of the binge eating scale, questionnaire for eating and weight patterns-revised, and eating disorder examination questionnaire with instructions with the eating disorder examination in the assessment of binge eating disorder and its symptoms. Int J Eat Disord 2004;36:434-444.
- Rief W, Hiller W. A new approach to the assessment of the treatment effects of somatoform disorders. Psychosomatics 2003;44:492-498.
- Chilcot J, Norton S, Wellsted D, et al. The factor structure of the Revised Illness Perception Questionnaire (IPQ-R) in end-stage renal disease patients. Psychol Health Med 2012;17:578-588.
- McCracken LM, Zayfert C, Gross RT. The Pain Anxiety Symptoms Scale: development and validation of a scale to measure fear of pain. Pain 1992;50:67-73.
- McCracken LM, Dhingra L. A short version of the Pain Anxiety Symptoms Scale (PASS-20): Preliminary development and validity. Pain Res Manag 2002;7:45-50.
- Swartzman LC, Gwadry FG, Shapiro AP, et al. The factor structure of the Coping Strategies Questionnaire. Pain 1994;57:311-316.
- Robinson ME, Riley JL, 3rd, Myers CD, et al. The Coping Strategies Questionnaire: A large sample, item level factor analysis. Clin J Pain 1997;13:43-49.
- Osman A, Barrios FX, Kopper BA, et al. Factor structure, reliability, and validity of the Pain Catastrophizing Scale. J Behav Med 1997;20:589-605.
- Osman A, Barrios FX, Gutierrez PM, et al. The Pain Catastrophizing Scale: further psychometric evaluation with adult samples. J Behav Med 2000;23:351-365.
- Austin DW, Richards JC, Klein B. Modification of the body sensations interpretation questionnaire (BSIQ-M): validity and reliability. J Anxiety Disord 2006;20:237-251.
- Peterson RA, Heilbronner RL. The anxiety sensitivity index: Construct validity and factor analytic structure. J Anxiety Disord 1987;1:117-121.
- Taylor S, Zyolensky MJ, Cox BJ, et al. Robust dimensions of anxiety sensitivity: Development and initial validation of the Anxiety Sensitivity Index-3. Psychol Assess 2007;19:176-188.
- Biggs AM, Aziz Q, Tomenson B, et al. Effect of childhood adversity on health-related quality of life in patients with upper abdominal or chest pain. Gut 2004;53:180-186.
- Fiddler M, Jackson J, Kapur N, et al. Childhood adversity and frequent medical consultations Gen Hosp Psych 2004;26:367-377.
You must be logged in with a subscription to access this page. Click here to login.